MSNBC's Lawrence O'Donnell challenged former disgraced Rep. Anthony Weiner, D-N.Y.'s desperate attempt to regain his political standing by running for mayor of New York City.

"What I find strange about your campaign is what seems to be your absolute desperate need for elective office and what seems to be your inability to live outside of it," O'Donnell asserted, repeated asking Weiner the question, "What is wrong with you?"

Weiner quickly grew hostile with O'Donnell and engaged in a heated debate.

O'Donnell explained he didn't have a problem with Weiner's embarrassing personal behavior but said it was irresponsible for Weiner to seek elected office again when he knew that his personal history would continue to damage his political career.

"What are you going to do after you lose Anthony?" asked O'Donnell.

"I don't plan on losing," Weiner replied, and added, "Maybe I'll come on this show and kick your ass every night like I'm doing tonight."