CNN reporter Christiane Amanpour argued Wednesday that the deck is stacked against women in politics, and that voters have an "issue" with women that may have prevented Hillary Clinton from winning the White House last year.

"There is an underlying issue with women," Amanpour said on CNN Wednesday morning.

"Certainly women who seek the highest offices. Certainly, women who have the temerity to demand equal pay for equal play," she added. "Certainly with these structures of society as they are, you know, laid out right now."

Her remarks followed a Tuesday interview with Clinton, in which Clinton blamed her loss on FBI Director James Comey and WikiLeaks. She also blamed her loss on Russia's alleged interference with U.S. voters, after Amanpour asked if she was a "victim of misogyny."

"It is real, it is very much a part of the landscape politically," Clinton said when asked how and why she lost support among white women.