Just six months after he cut a fiscal cliff deal with Senate Minority Leader Mitch McConnell, Vice President Joe Biden declared Friday night that the GOP has no adult leadership and he said it is being pushed around by two "bright new guys," Sens. Ted Cruz of Texas and Rand Paul of Kentucky.

"This is not your father's Republican Party, it's fundamentally different," he said at a San Francisco Democratic Party fundraiser. "There's no one with whom to deal with and there's no one in charge anymore."

In December and January, Biden worked closely with senior GOP leaders like McConnell to work out a budget deal that halted the nation's fall over the so-called fiscal cliff.

But in his 10 minute address at the home of Dawn Ross and Doug Hickey, the CEO of BinWise, a beverage distribution company in San Francisco, Biden forgot all that to slam the emergence of Tea Party-backed Cruz and Paul, part of the group GOP Sen. John McCain dubbed "wing nuts."

With a sweeping view of the Golden Gate Bridge behind him and as guests noshed on Mexican mushroom empanadas and British beef and cheese pub pie, Biden blasted the conservative duo. "They are the ones that control the Republican Party right now, literally," he said. "I've never seen a time in all the years I was in the Senate that two freshmen have so much impact on the entirety of the Republican party."

Biden added, "America has moved on, well beyond where these guys are."

As he spoke, crowd of about 50 protesters opposing the Keystone XL pipeline demonstrated, according to the pool report on the vice president's event. Local news made a big deal of the protests.