Democrats are already signaling that the stewardship of Obamacare will be a major issue in the confirmation of the next secretary of Health and Human Services.
Tom Price resigned as secretary Friday amid a scandal over his use of private jets.
Whoever President Trump picks to replace him could face major questions over how he or she will run Obamacare, as Democrats have criticized HHS for trying to sabotage the law.
Several Democratic senators on Friday alluded to what they are looking for in the next secretary. Trump named agency veteran Don Wright acting secretary while he looks for a replacement.
"It is critical that the next secretary of Health and Human Services commits to immediately dropping the Trump administration's attempts to sabotage healthcare markets," said Sen. Maggie Hassan of New Hampshire.
Sen. Ron Wyden of Oregon tweeted that Trump should "nominate someone who is looking out for the taxpayers & the country." Wyden is the top Democrat on the Senate Finance Committee, which will vote on the nomination before it hits the Senate floor.
Trump's options could include agency heads such as Centers for Medicare and Medicaid Services Administrator Seema Verma, who worked with Vice President Mike Pence on Indiana's Medicaid program when he was governor.
Another option is Food and Drug Administration Commissioner Scott Gottlieb, who received some bipartisan support when he was confirmed 57-42 in May.
Trump also can turn to Congress again to find his next secretary. Price, an orthopedic surgeon, served in the House for more than a decade before becoming HHS secretary in February.
Sen. Catherine Cortez Masto, D-Nev., tweeted that she hopes the next HHS secretary is focused more on "bipartisanship to fix what's not working in [the Affordable Care Act]. Americans have real concerns over their care."
Democrats and outside Obamacare advocacy groups have been criticizing HHS in the runup to open enrollment, which starts Nov. 1. Among the criticisms are that HHS cut in half the open enrollment season, running the period from Nov. 1 to Dec. 15.
They also point to HHS actions that include slashing advertising and outreach as evidence that the agency is sabotaging Obamacare.
And they are highlighting repeated comments from Trump that he should let Obamacare "implode" because it may create pressure on Democrats to embrace Obamacare repeal.
Congressional Democrats sent a letter to Price Friday, before he resigned, excoriating the agency for prohibiting regional HHS staff from attending local Obamacare outreach events.
Efforts to repeal Obamacare are likely on hold for the moment as congressional Republicans shift their focus to tax reform. The GOP introduced a budget resolution Friday that wouldn't let Republicans use reconciliation to repeal Obamacare with only 51 votes.