House Speaker Paul Ryan, R-Wis., urged Senate Republicans on Friday to continue working on a plan to repeal and replace Obamacare following a failed vote early Friday morning on a "skinny" bill repealing parts of the healthcare law.

"We were sent to Washington to fulfill the pledges we made to our constituents. While the House delivered a bill to repeal and replace Obamacare, unfortunately the Senate was unable to reach a consensus," Ryan said in a statement Friday. "I am disappointed and frustrated, but we should not give up. I encourage the Senate to continue working toward a real solution that keeps our promise."

The Senate voted early Friday morning on a bill that repealed provisions of Obamacare, but the plan was ultimately voted down 49-51 after three Republican senators — Susan Collins of Maine, John McCain of Arizona, and Lisa Murkowski of Alaska — joined with Democrats and voted "no."

Senate Majority Leader Mitch McConnell said Friday it was time for the Senate to move on, and Ryan continued to press forward with the GOP's agenda, saying House Republicans will move on to tax reform next.

"We have so much work still to do, and the House will continue to focus on issues that are important to the American people," he said. "At the top of that list is cutting taxes for middle class families and fixing our broken tax code. I'm glad that members will now take time to hear directly from those they represent and make the case for historic tax reform that we intend to pursue in the fall."