The head of the Republican National Committee issued a warning to Republican senators who oppose President Trump and urged them to look at those who lost their seats in 2016 as a "cautionary tale."

"If you look at 2016, the senators that did not support the president, and let's look at Joe Heck and Kelly Ayotte, they fell short in those Senate races, so there is a cautionary tale there because voters want you to support the president in his agenda," RNC Chairwoman Ronna McDaniel said Tuesday in an interview on Laura Ingraham's radio show.

Both Heck, R-Nev., and Ayotte, R-N.H., as well as former Sen. Mark Kirk, R-Ill., lost their Senate races and were critical of Trump during the 2016 campaign.

McDaniel was discussing Sen. Jeff Flake, R-Ariz., who is up for re-election in 2018 and has recently spoken out against Trump's policies and rhetoric.

Ingraham asked McDaniel if Flake could be removed from the Republican ticket, and the RNC chairwoman said though the committee typically doesn't intervene in primaries, the RNC could step in if committee members agreed to take such action.

"They need to have another candidate that they supported and the three RNC members that have to agree on that other candidate for rule 11 to apply, but it is in their bylaws," McDaniel said. "It's just interesting from a party standpoint, we do have governance. We have 168 members that they make those decisions."