The office of House Speaker Paul Ryan said Wednesday that next week's scheduled vote to repeal key parts of Obamacare will be the best chance Republicans have had for years to repeal the law that they've fought since it President Obama signed it in 2010.

"This is our best shot to stand up for our principles on behalf of the American people," Ryan's office said in a statement.

"In doing so, we're forcing the president to confront the failures of this law once and for all," the statement added. "We owe it to the country to take our best shot at repealing Obamacare, and that's what we will do next week."

Republicans are finally expected to send a repeal bill to Obama's desk, as they used the budget reconciliation process to create a repeal bill that is immune from Democratic filibusters in the Senate. The Senate already passed the bill in a 52-47 vote in December, and the House will easily pass it next week with GOP support.

But just sending the bill to Obama doesn't mean it will become law. Obama is free to veto it, and there won't be enough support in the House or Senate to override that veto.

Still, Ryan's office praised the bill for effectively repealing the health insurance mandates and taxes required under the law. It would also defund Planned Parenthood, a goal the GOP has pursued ever since videos were released showing that officials from the healthcare and abortion provider were haggling over the price of aborted fetal remains.

"Americans should not be forced to fund this organization," Ryan's office said. "That's why Congress will act to defund Planned Parenthood, and shift those resources to community health centers."

The statement noted that congressional action has led to at least 10 changes to the healthcare law over the last several years. It also said the 2016 funding bill delayed a medical device tax and prohibited a government bailout of health insurance companies.