The Senate voted 55-43 on Tuesday to confirm Amy Coney Barrett to the 7th Circuit Court of Appeals.

Three Democrats crossed party lines to vote for Barrett: Indiana Sen. Joe Donnelly, Virginia Sen. Tim Kaine and West Virginia Sen. Joe Manchin. Donnelly is running for re-election in Barrett's home state.

Barrett, a Notre Dame law professor, came under fire from Senate Democrats because of her Catholic faith during Senate Judiciary Committee hearings on her nomination. Democratic Sens. Dianne Feinstein of California and Dick Durbin of Illinois grilled Barrett at the hearings over how she chooses to practice her Catholic faith.

The questions from Senate Democrats spawned an attack ad from the right-leaning Judicial Crisis Network with funding in the six figures. The moment also led to Senate Majority Leader Mitch McConnell joining Senate Judiciary Committee Chairman Chuck Grassley and seven of their GOP colleagues to speak in favor of her nomination Monday as the Senate invoked cloture by a 54-42 vote.

"Professor Barrett is a brilliant legal scholar who has earned the respect of colleagues and students from across the political spectrum," Grassley said Monday. "She's also a committed Roman Catholic and has spoken passionately about the role that her faith plays in her life. This isn't inconsistent with being a federal judge."

Barrett's confirmation Tuesday to the Midwestern federal appeals court makes her the first Hoosier woman on the 7th Circuit Court of Appeals.