“I gotta tell you, tonight I am angry, and for once that doesn’t make me happy,” comedian Stephen Colbert said during his show’s opening. “And I think you know why. My sister lost!”

Colbert’s sister, Elizabeth Colbert Busch, lost in Tuesday’s congressional special election to disgraced former South Carolina Gov. Mark Sanford.

Colbert admitted to his audience that the voters of his home state had spoken, but that he felt betrayed.

“If they’re going to turn their back on my family, I’m going to turn my back on South Carolina,” Colbert said, suggesting that he would switch allegiances to North Carolina.

After gagging over North Carolina barbecue, Colbert changed his mind.

“I can’t do it. I love South Carolina too much. And I love my sister. And I’m so proud of her.” Colbert said, wondering where she went wrong in the campaign.

“I got to tell you this scares me to my core. I’m shaken,” Colbert added, noting that his sister was the first political candidate that he knew and cared about before going into politics.

Later in the show, Colbert did a stunt using helium to alter his voice while discussing political partisanship.

“Fu%k Mark Sanford,” he joked.