Fox News debate moderator Chris Wallace rejected Texas Sen. Ted Cruz's attempts to interrupt during Thursday night's GOP presidential debate in Iowa. Cruz tried to interject himself into the debate ahead of former Florida Gov. Jeb Bush.

"Sir … I know you like to argue about the rules, but we are going ahead with the debate," Wallace told Cruz.

Cruz next tried to chime in after New Jersey Gov. Chris Christie answered a question from Wallace that mentioned Cruz's name.

"It's not my question you have a chance to respond to, it's his answer," Wallace said. "You don't get 30 seconds to respond to me."

When Cruz was next provided the opportunity to speak, his answer appeared to be met with a poor response from the audience in Des Moines.

"I would note that the last four questions have been Rand, please attack Ted, Chris please attack Ted, Jeb please attack Ted," Cruz said to boos that could be heard on Fox News' broadcast. "Let me just say this."

"It is a debate, sir," Wallace interrupted.

"No, no," Cruz replied. "A debate actually is a policy issue but I will say this, gosh if you guys ask one more mean question, I may have to leave the stage."

Cruz's answer may have been a tongue-in-cheek jab at Donald Trump, who skipped the debate, but the punchline fell flat.

When Florida Sen. Marco Rubio had the chance to speak next, he prefaced his remarks with a statement.

"First of all, don't worry," Rubio said, "I'm not leaving the stage no matter what you ask me."