The U.S. Department of the Treasury announced Wednesday that it is targeting six leaders of the MS-13 gang — including one man who authorities say ordered two slayings in the Washington area — in an effort to disrupt the gang's activities and protect the organization from abusing the U.S. and international financial system.

Any of the six gang leaders' assets that are subject to U.S. jurisdiction are frozen, and U.S. citizens and businesses are generally prohibited from doing business with the leaders, Treasury officials said.

The six MS-13 leaders who were singled out by the Treasury Department are from El Salvador. Three of the leaders have been indicted in the D.C. region.

Moises Humberto Rivera-Luna, 44, and Marvin Geovanny Monterrosa-Larios, 39, were indicted in November 2011 in federal court in the District. The men, who are incarcerated in El Salvador, allegedly directed that a coalition of MS-13 cliques be formed in the D.C. region. A purpose of the coalition would be to kill MS-13 members who were cooperating with law enforcement, according to the indictment.

Rivera-Luna allegedly sent orders and advice to an MS-13 clique in the D.C. area by making telephone calls from a prison cell. He also ordered a 2008 Northwest D.C. slaying and a 2010 Montgomery County slaying, prosecutors said.

Saul Antonio Turcios Angel, 35, was indicted in federal court in Greenbelt in 2007 on a charge of conspiracy to participate in a racketeering enterprise, court records show.

The other three MS-13 members who were targeted by the Treasury Department were Moris Alexander Bercian Manchon, 28, Jose Misael Cisneros Rodriguez, 36, and Borromeo Enrique Henriquez Solorzano, 34.

MS-13 consists of more than 30,000 members and operates in at least five countries, including the United States. In October, the Treasury Department designated the gang as a transnational criminal organization.

Members of MS-13 have been convicted of a number of crimes in the D.C. area. Last week, a man was convicted in Prince George's County in the stabbing of a former MS-13 member who testified against three members during a 2010 trial, prosecutors said.