"That will not happen," Pfeiffer said.
The comments come after the House voted Friday to delay the mandate by a decade. The lower chamber has attempted unravel President Obama's signature domestic policy many times before, and the effort is dead on arrival in the Senate.
But the vote came after Democrats lost a tight Florida special election that largely focused on Obamacare.
The results have some Democrats fearing Obamacare might be "political poison," suggested "Meet the Press" host David Gregory.
"I believe we will keep the Senate," Pfeiffer said.