Environmental Protection Agency Administrator Andrew Wheeler directed his department to phase out the use of animal research and allocated $4.25 million to advance research on alternative methods that can better predict potential hazards.

In a memo signed on Tuesday, Wheeler outlined the EPA’s plan to reduce requests for and funding of mammal studies by 30% by 2025, and to eliminate such requests and funding by 2035. Any mammal studies requested or funded after 2035 will require administrator approval on a case-by-case basis.