Democrats are betting they can translate a changing cultural and political landscape into a break-glass-ceiling moment for women after former Secretary of State Hillary Clinton’s loss to Donald Trump in 2016.

President Joe Biden’s decision to end his campaign and endorse Vice President Kamala Harris has given a jolt to Democrats who questioned his fitness for a second term. Her candidacy has even invited comparisons to the history-making run of Barack Obama, the nation’s first black president.