The Wirefly National Marathon kicks off at 7 a.m. Saturday, taking nearly 5,000 runners on a 26.2-mile tour of the District and temporarily shuttering most major commuter entrances and exits around the city .

The race is scheduled to start and finish at RFK Stadium. It takes runners onto about 50 District roads, covering much of downtown and the National Mall, and venturing into every city quadrant before returning to East Capitol Street and the D.C. Armory.