Marc Kudisch gravitates to the devil whenever the opportunity arises. Direct from playing the serpent who tempts Eve (and two other roles) in the Broadway hit “The Apple Tree,” he slithers into the deliciously wicked persona of Daryl Van Horne in “The Witches of Eastwick” at Signature Theatre.

Eric Schaeffer is directing the American premiere of the musical that he staged for its 2000 opening in London’s West End. Along with Kudisch, the new production boasts Broadway stars Emily Skinner, Christiane Noll and Jacquelyn Piro Donovan as the women whose ideal man materializes as the devil.