In the first act of Wendy Wasserstein’s “The Sisters Rosensweig,” Pfeni (Lisa Hodsoll), a noted travel writer, presents her niece, Tess (Jessica Behar), with a statue of the Hindu god Shiva the Destroyer, with the wish that it will bring her “hope and rebirth.”

It’s a theme that carries the play, as peripatetic Pfeni and her larger-than-life sister “Dr. Gorgeous” (Amy Jo Shapiro), a radio personality, converge on the London home of their eldest sibling, Sara (Lynda McClary), a successful international banker, for her birthday in 1991.