Democratic operative James Carville is not optimistic that his party will be able to take back the Senate in the 2018 midterm elections.

"I would say we have a pretty good chance of taking the House back. The Senate is very, very difficult," the Clinton loyalist told the John Catsimatidis radio show.

"The problem in the Senate is we have a large number of seats we have to hold in states that Donald Trump carried. Indiana, Missouri, you know, places like that we have to hold seats," he said.

Carville sees Democrats as having a chance in Nevada, but less so in Arizona, Texas, and Alabama.

"They have to pick up three seats," Carville said.

However, Republicans in the Senate are facing intense pressure to repeal and replace Obamacare, a promise they've made to constituents for years.

The unpopularity of the bill could work in the favor of Democrats, Carville argued.

"Anybody that moves to change healthcare loses," he said.