Donald Trump escalated his assault on Supreme Court Justice Ruth Bader Ginsburg early Wednesday morning by calling for her resignation after remarks this week slamming the presumptive GOP nominee.

Taking to his preferred method of launching quick attacks on opponents, Trump tweeted an hour past midnight that Ginsburg "has embarrassed all by making very dumb political statements about me."

He added: "Her mind is shot - resign!"

Trump's brief message follows an interview with the New York Times published Tuesday in which he called the justice "a disgrace" for her "highly inappropriate" remarks. He also demanded that she apologize to her colleagues on the Supreme Court.

Earlier in the week during interviews with the Times and the Associated Press, Ginsburg said she didn't want to "contemplate" a Trump presidency. She later escalated her critique, calling Trump a "faker," slamming the billionaire for his lack of consistency on the campaign trail, and chided him for not releasing his tax returns. Trump has said he does not want to release his tax returns while he is being audited.

Ginsburg also said she expects Democratic candidate Hillary Clinton to become the next president.

Her comments have shocked legal experts and politicians alike, who have pointed to the problems Ginsburg might face with real or perceived impartiality should the Supreme Court consider a case involving Trump or one of his policies should he become president.

House Speaker Paul Ryan told CNN Tuesday evening that Ginsburg's "bias" was "out of place."

"For someone on the Supreme Court, who is going to be calling balls and strikes in the future based upon whatever the next president and Congress does," Ryan told CNN's Jake Tapper. "That strikes me as inherently biased and out of the realm," Ryan said. "I don't think that that shows that she intends on being impartial in the future."