Sen. Arlen Specter lost his bid for a sixth term, succumbing in the Democratic primary to relative newcomer Joe Sestak, a two-term congressman who successfully campaigned against Specter’s recent party switch.

Specter’s loss represents the biggest rebuke of incumbent lawmakers so far this year. Longtime Rep. Alan Mollohan, D-W.Va., lost his primary last week and Sen. Bob Bennett, R-Utah, was rejected for the GOP ballot by his own party 10 days ago.

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