ISTANBUL (AP) — Turkish artillery fired on Syrian targets after deadly shelling from Syria hit a Turkish border town on Wednesday, sharply raising tensions on a volatile border that has been crossed by tens of thousands of Syrian refugees fleeing violence in their country.

In a terse statement, the office of Turkey’s prime minister, Recep Tayyip Erdogan, condemned shelling that hit the Turkish town of Akcakale, killing five local residents and wounding a dozen others. The shelling appeared to come from Syrian government forces who were fighting Syrian rebels backed by Turkey, which has called for the ouster of Syrian President Bashar Assad.