WASHINGTON (AP) — He’s tackled the financial crisis, served two vice presidents and been portrayed by Kevin Spacey in an HBO film, but Ron Klain’s newest job as the U.S. point person on Ebola may be his toughest challenge to date.

A longtime Democratic operative, Klain was tasked Friday by President Barack Obama with running the government’s response to the Ebola crisis. Klain has been a trusted adviser at the Obama White House, and served as Vice President Joe Biden’s chief of staff from 2009 to 2011 and as Vice President Al Gore’s from 1995 to 1999.