All three major U.S. equity indexes closed on Friday with losses, capping off one of the worst weeks for markets in a decade as the Federal Reserve’s decision to raise interest rates and a looming government shutdown continue to spook investors.

The Dow Jones Industrial Average closed down 414 points to 22,445, marking a more than 1,100-point loss for the exchange since Monday in its worst week since the 2008 financial crisis. Similarly, the Nasdaq was down 195 points and the broader S&P 500 decreased 50 points to an 18-month low.