The Senate is headed for a grueling “vote-a-rama” after Senate Majority Leader John Thune (R-SD) signaled Tuesday he would bring tens of billions in border funding to the floor this week.

Democrats will be unable to stop the Senate resolution, a $340 billion measure that covers the border, energy, and defense, from advancing if nearly all Republicans stick together, thanks to a legislative process called reconciliation that allows Thune to bypass the filibuster.