EAST ST. LOUIS, Ill. (AP) — German drugmaker Boehringer Ingelheim said Wednesday it has agreed to pay $650 million to settle thousands of U.S. claims questioning the marketing and safety of its popular blood thinner Pradaxa.

The company said the settlement, filed in federal court in East St. Louis, resolves roughly 4,000 claims, paying out an average of $162,500 per case.