Lawmakers are getting angry over a new price hike for a drug, this time targeting a cancer drug whose price was raised four times this year alone.

Former presidential candidate Sen. Bernie Sanders, I-Vt., and Rep. Elijah Cummings, D-Md., sent a letter Thursday to Ariad Pharmaceuticals for answers about Iclusig, which treats a bone marrow cancer that makes too many white blood cells. Sanders and Cummings, who have targeted high-priced drugs, said Ariad has added more than $80,000 to the drug’s already high price tag this year.