News that Sen. Jeff Flake, R-Ariz., will not seek re-election has set off a scramble among Republicans considering a run for what will now be an open seat as the party tries to hold onto its narrow majority of 52 seats.

At the moment, multiple Republican lawmakers are looking at jumping into the contest against Rep. Kyrsten Sinema, D-Ariz., her party’s likely nominee. Prominent Republicans viewed as possible candidates with Flake out are Rep. Martha McSally, R-Ariz. and Rep. David Schweikert, R-Ariz.