THE HAGUE, Netherlands (AP) — Former Bosnian Serb leader Radovan Karadzic should be sentenced to life imprisonment if he is convicted of “a substantial portion” of the crimes he stood trial for at a U.N. war crimes tribunal, prosecutors said in a written brief published Friday.

Summing up their vision of Karadzic’s trial, prosecutors called him the “pre-eminent political and military leader of the Bosnian Serbs and their forces” during the 1992-95 war in Bosnia that left 100,000 people dead.