The centrists of the Senate may be about to make their power play in the 50-50 chamber, controlled by the Democrats only due to Vice President Kamala Harris’s tiebreaking vote.

Sen. Susan Collins, a Maine Republican, joined her Democratic colleague from West Virginia in opposition to President Biden’s nominee to run the Office of Management and Budget on Monday. “Neera Tanden has neither the experience nor the temperament to lead this critical agency,” she said in a statement. “Her past actions have demonstrated exactly the kind of animosity that President Biden has pledged to transcend. … I will vote against confirming Ms. Tanden.”