Senate Republicans are poised “to go nuclear” and blow up Senate rules to seat Judge Neil Gorsuch on the Supreme Court and appear to have the votes to follow through on their threat now that a Democratic-led filibuster appears inevitable.

Sen. John Cornyn, R-Texas, the second-highest ranking GOP leader and top vote-counter, said Monday that Gorsuch would be confirmed by the end of the week, signaling that Republicans are ready and willing to invoke the nuclear option to confirm Gorsuch in the face of mounting Democratic opposition.