A nationwide healthcare fraud crackdown resulted in charges against 455 defendants accused of schemes involving more than $6.5 billion in fraudulent claims, marking what federal officials on Tuesday described as the largest coordinated healthcare fraud enforcement action in Justice Department history.

Acting Attorney General Todd Blanche, Health and Human Services Secretary Robert F. Kennedy Jr., FBI Director Kash Patel, and Centers for Medicare & Medicaid Services Administrator Mehmet Oz announced the operation, which spanned 57 federal districts across 41 states and territories and included charges against 90 licensed medical professionals.