Iran or a number Islamic terrorist groups may react violently on Tuesday, when the U.S. officially opens its new embassy in Jerusalem. While the embassy’s opening coincides with Israel’s 70th anniversary, it also falls on a day when Hamas will lead thousands of Palestinians in an aggressive march on the Israeli border.

The operative concern here is that Jerusalem has a defining ideological importance for every Islamic extremist entity that targets Israel. This includes the Iranian hardliners aligned with the Islamic Revolutionary Guards Corps, Hamas, the Palestinian Islamic Jihad, and the Lebanese Hezbollah. As home to the Al-Aqsa mosque (the third holiest mosque in Islam) these entities see Jerusalem as a physical and theological sacrament that must be liberated from Israel.